Trabecular scaffolds created using micro CT guided fused deposition modeling.

TitleTrabecular scaffolds created using micro CT guided fused deposition modeling.
Publication TypeJournal Article
Year of Publication2009
AuthorsTellis BC, Szivek JA, Bliss CL, Margolis DS, Vaidyanathan RK, Calvert P
JournalMater Sci Eng C Mater Biol Appl
Volume28
Issue1
Pagination171-178
Date Published2009 Jan 10
ISSN1873-0191
Abstract

Free form fabrication and high resolution imaging techniques enable the creation of biomimetic tissue engineering scaffolds. A 3D CAD model of canine trabecular bone was produced via micro CT and exported to a fused deposition modeler, to produce polybutylene terephthalate (PBT) trabeculated scaffolds and four other scaffold groups of varying pore structures. The five scaffold groups were divided into subgroups (n=6) and compression tested at two load rates (49 N/s and 294 N/s). Two groups were soaked in a 25 °C saline solution for 7 days before compression testing. Micro CT was used to compare porosity, connectivity density, and trabecular separation of each scaffold type to a canine trabecular bone sample. At 49 N/s the dry trabecular scaffolds had a compressive stiffness of 4.94±1.19 MPa, similar to the simple linear small pore scaffolds and significantly more stiff (p<0.05) than either of the complex interconnected pore scaffolds. At 294 N/s, the compressive stiffness values for all five groups roughly doubled. Soaking in saline had an insignificant effect on stiffness. The trabecular scaffolds matched bone samples in porosity; however, achieving physiologic connectivity density and trabecular separation will require further refining of scaffold processing.

DOI10.1016/j.msec.2006.11.010
Alternate JournalMater Sci Eng C Mater Biol Appl
PubMed ID21461176
PubMed Central IDPMC3065838
Grant ListR01 EB000660-02 / EB / NIBIB NIH HHS / United States
R01 EB000660-03 / EB / NIBIB NIH HHS / United States
R01 EB000660-02S1 / EB / NIBIB NIH HHS / United States
R01 EB000660 / EB / NIBIB NIH HHS / United States
R01 EB000660-04 / EB / NIBIB NIH HHS / United States